MATα1 also interacts with p53 and DNA damage-regulated gene 1 in hepatoma cells.129 Furthermore, SAM treatment altered the homeostasis of MAT1A and MAT2A by altering the balance of AUF1 and methyl-HuR/HuR, which was first identified to inhibit MAT2A mRNA stability.153 SAM maintains MAT1A expression, but inhibits MAT2A expression, in hepatocytes. Here, MAT2A is linked to hepatocellular carcinoma.