After SAM administration, the antiviral effect of IFN was enhanced.59 Feld et al. also showed that adding SAM to peginterferon (PEG-IFN) and ribavirin improves the kinetics of the early antiviral response.60 Sonia Amelia Lozano-Sepulveda et al. suggested that SAM can diminish HCV expression in cells partly by modulating antioxidant enzymes, synthesizing GSH, and switching the MAT1A/MAT2A turnover.57 The MAT1A/MAT2A ratio is relevant to the survival of patients with HCC.61 This transformation may be conducive to the transition of viral hepatitis to liver cancer. Here, IFNA1 is linked to hepatocellular carcinoma.