In conclusion, as an important part of one-carbon metabolism, methionine metabolism is closely related to diverse pathophysiological processes.19 Accumulating preclinical evidence indicates that alterations in the methionine cycle play a pathogenetic role in CLD.38 The switch of MAT1A to MAT2A/MAT2B reduces the levels of SAM, which is an essential factor in fibrosis and liver cancer.129 Preventing or even reversing this transformation will be the direction of future research. Here, MAT2A is linked to congenital secretory chloride diarrhea 1.