MAT1A and metabolic dysfunction-associated steatotic liver disease: CD36 content significantly augments in MAT1A-KO mice.92 Increasing the CD36 level contributes to hepatic TG storage.99 Besides, the levels of Hcy, an intermediary in liver methionine metabolism, are elevated in patients with NAFLD.100 Elevated serum Hcy concentrations are related to the histological severity of NAFLD.101 However, high serum Hcy levels are negatively associated with NASH, and significant fibrosis in patients with NAFLD.