MAT2A and hepatocellular carcinoma: After SAM administration, the antiviral effect of IFN was enhanced.59 Feld et al. also showed that adding SAM to peginterferon (PEG-IFN) and ribavirin improves the kinetics of the early antiviral response.60 Sonia Amelia Lozano-Sepulveda et al. suggested that SAM can diminish HCV expression in cells partly by modulating antioxidant enzymes, synthesizing GSH, and switching the MAT1A/MAT2A turnover.57 The MAT1A/MAT2A ratio is relevant to the survival of patients with HCC.61 This transformation may be conducive to the transition of viral hepatitis to liver cancer.