MAT2A and animal viral hepatitis: Deregulation of m6A regulators in host hepatocytes may contribute to the development of viral hepatitis.42 Methionine metabolism is closely related to m6A methylation.42,43 A study revealed a mechanism of homeostatic regulation of SAM synthesis in mammalian cells that involves dynamic m6A modifications in the MAT2A 3′ UTR.44 After methionine depletion, splicing of the MAT2A-retained intron is rapidly induced.45