A recent report on melanoma revealed that long-term mTOR kinase inhibition leads to re-activation of both pAkt S473 and pAkt T308 and that induction of IGF1R/IR-dependent PI3K activation and Akt phosphorylation is mediated by an integrin/focal adhesion kinase/IGFR-dependent process (46). The gene discussed is INSR; the disease is melanoma.