Indeed, initial studies found that the unfolded p53 protein was able to discriminate AD patients from non-AD controls, due to a significantly higher expression of this conformationally altered isoform in peripheral blood mononuclear cells (PBMCs) from overt AD patients (CDR 1.5–2 and MMSE: 17) [70–72]. The gene discussed is TP53; the disease is Alzheimer disease.