MTOR and Alzheimer disease: As mentioned earlier, mTOR signaling is also increased in human brain samples of patients affected by amnestic MCI (soluble Aβ1–42 concentration: 29.7 fmol/mg and MMSE: 23.3) and AD (soluble Aβ1–42 concentration: 35.1 fmol/mg and MMSE: 12.9) in comparison with healthy controls (soluble Aβ1–42 concentration: 8.08 fmol/mg and MMSE: 28.7) [50].