This p53-induced antioxidant response may also be neuroprotective in vivo, as glutathione was found to be decreased in the hippocampi of patients with mild cognitive impairment (MCI) (CDR 0.7 and Mini-Mental State Examination [MMSE]: 25.5) and AD (CDR 1.5 and MMSE: 18.4). This evidence concerns the gene TP53 and Cognitive impairment.