For instance, a recent single-cell RNA sequencing study in postmortem brain tissue from Alzheimer’s disease cases discovered a subtype of “disease-associated microglia” (DAM), with a unique transcriptional and functional profile, characterized by high phagocytic activity and upregulation of specific markers such as TREM2 [43]. The gene discussed is TREM2; the disease is early-onset autosomal dominant Alzheimer disease.