In addition to the hypermutated subtypes of endometrial, bladder, and colorectal cancers, we also observed high TMB subgroups with concurrently high expression of CD8 T cell markers in the cervical cancer c1 subtype (Additional file 1: Fig. S4a and S5a), head and neck cancer c4 subtype (Additional file 1: Fig. S4c, S5c), lung adenocarcinoma c3 subtype (Additional file 1: Fig. S4f and S5f), lung squamous cell carcinoma c4 subtype (Additional file 1: Fig. S4g and S5g), and stomach cancer c1 subtype (Additional file 1: Fig. S4h and S5h). The gene discussed is CD8A; the disease is head and neck cancer.