ZC3H12D and thalassemia: We further divided the β0/β0 thalassemia patients into two subgroups: subjects with age < 5 years old (Fig. 1d) and subjects with 5–15 years old (Fig. 1e), and observed that the TFH patients still displayed significant lower methylation levels than the TFL patients, especially for the subjects with 5–15 years old (Fig. 1e).