Since endothelium dysfunctions associated to low magnesium medium, are reversible following magnesium supplementation (such as normal proliferation rate, increase of NO release and reduction of MMP9 and NFKB activity [27]), strategies aimed to screen and increase intracellular magnesium content are fundamental to counteract vascular dysfunction due to physiological aging process, diabetes or unhealthy life styles promoting obesity and atherosclerosis. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.