MMP9 and Obesity: Since endothelium dysfunctions associated to low magnesium medium, are reversible following magnesium supplementation (such as normal proliferation rate, increase of NO release and reduction of MMP9 and NFKB activity [27]), strategies aimed to screen and increase intracellular magnesium content are fundamental to counteract vascular dysfunction due to physiological aging process, diabetes or unhealthy life styles promoting obesity and atherosclerosis.