CD19 and plasma cell myeloma: Although this is in sharp contrast with what has been observed in studies with CD19 CAR-T cells [60, 61], this meta-analysis pointed to a higher risk of neurotoxicity in BCMA CAR-T-cell studies in which the median patient age was ≥ 60 years and/or in which the median number of prior lines of anti-myeloma treatments was ≥ 5.