On ex vivo stimulation with CD3 and TLR7/8, T-cells from patients with severe CAP (non-COVID-19 and COVID-19), as compared to non-infectious controls, displayed a significantly decreased production of INF-γ, TNF-α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-15, IL-17A and IL-33, with no difference between COVID-19 and non-COVID-19 groups (Fig. 2a–d, Additional file 1: Table S3). This evidence concerns the gene IL4 and COVID-19.