Although PaO2:FiO2 ratio and SOFA score were not different between groups (p = 0.35 and p = 0.52, respectively), fewer COVID-19 patients had septic shock (0 vs. 11 (31%); p = 0.0015), and arterial lactates (p = 0.01), serum creatinine (p = 0.02), and NT-proBNP (p = 0.0003) were all lower in COVID-19 patients (Table 1). This evidence concerns the gene NPPB and septic shock.