CD274 and hepatocellular carcinoma: In turn, Reck et al. hypothesized that the similarity of NSCLC liver metastasis to hepatocellular carcinoma (HCC) might explain why the combination therapy of atezolizumab + bevacizumab + carboplatin and paclitaxel (ABCP) showed superiority in terms of PFS and OS compared with atezolizumab and chemotherapy (ACP) despite lower PD-L1 expression in patients with liver metastases in the IMpower150 trial [10].