Concomitant TP53 mutation and Rb expression loss were unlikely to be predictors of choroidal metastasis, although it has been previously associated to SCLC histological transformation, since only three out of seven patients showed TP53/Rb double alterations with only a single patient exhibiting SCLC transformation upon EGFR TKI in our series. This evidence concerns the gene EGFR and small cell lung carcinoma.