APP and Alzheimer disease: We reported that the RyR2 channel undergoes PKA phosphorylation, oxidation/nitrosylation and depletion of the channel stabilizing subunit Calstabin2 in SH-SY5Y neuroblastoma cells expressing APP harboring the familial Swedish mutations (APPswe), in APP/PS1 (APPswe, PS1-M146V), as well as in 3xTg-AD, transgenic mice models and, most importantly, in human SAD brains [150,153].