Enhanced RyR-mediated Ca2+ release was reported in primary cultured neurons derived from 3xTg-AD mice (knock in (KI) for the mutated PS1M146V and overexpressing mutated APP and microtubule-associated tau protein (PS1M146V/APPswe/tauP301L)) [85,87]. This evidence concerns the gene RYR1 and Alzheimer disease.