RYR3 and Alzheimer disease: Overall, these results emphasize the broad implication of RyRs in ER Ca2+ signaling deregulation in AD occurring through the regulation of RYRs expression, CICR-dependent activity, macromolecular complex stability-linked to β2-AR signaling cascade, Aβ- and PS-mediated RyRs channel opening and likely RYR3 gene polymorphism.