PSEN1 and Alzheimer disease: The STIM2–SOCE–CaMKII pathway was downregulated in a PS1-M146V KI mouse model of AD, associated with loss of hippocampal mushroom spines [233], and conversely, STIM2 overexpression rescued synaptic SOCE and mushroom spine deficit in hippocampal neurons from PS1-M146V KI mice [233].