TNFSF13B and diabetes mellitus: For example, depletion of these cells in the Tnfsf13b transgenic mice (mice overexpressing BAFF), [89] NOD-Aec1Aec2 mice (showing SS-like disease progression without diabetes) [90] and Txlna-transgenic mice (increased numbers of B1 cells and marginal zone B cells) [91,92] restored normal salivary gland function and showed normal histological features for lacrimal and salivary glands.