A study by Azzolin et al. showed the β-catenin destruction complex, a multiprotein complex including the tumor suppressors axin and APC, sequester YAP and TAZ in cytoplasm when Wnt signaling is off, whereas β-catenin, YAP, and TAZ are separated from the destruction complex and activated when Wnt signaling is activated by APC depletion [124]. This evidence concerns the gene APC and neoplasm.