AIMP2 and cancer: Based on this mode of action of AIMP2-DX2, the protein–protein interaction inhibitor BC-DXI-495 (28) was found to specifically inhibit the AIMP2-DX2 + HSP70 interaction and suppress cancer cell growth in vitro (IC50 = 4.2 μM, luciferase assay; EC50 = 14.2 μM, cell viability assay, A549 cells) and AIMP2-DX2-induced tumor growth in vivo (~50% decrease, 50 mpk, ip [intraperitoneal injection], 2 weeks, H460 stably expressing AIMP2-DX2 WT [wild type], BALB/cSLC mice).