First, a recent work using a different CRISPRko library in glioblastoma stem cells treated with TMZ also revealed MMR genes as top gene candidates [27], and more recently, using U87MG and U87MG, EGFRvIII cells revealed that E2F6 controls TMZ resistance in EGFR mutates cells [28]. This evidence concerns the gene MRC1 and glioblastoma.