In a similar study, Gangemi et al. analyzed the serum levels of AOPPs and AGEs, and protein nitrosylation in patients with B-CLL, and found that whereas AOPPs, AGEs, and S-nitrosylated proteins are increased in patients, there is no correlation between any of these products and CD38 or ZAP70 expression, nor with mutations in the IgVH gene [19]. Here, ZAP70 is linked to B-cell chronic lymphocytic leukemia.