Several other studies have shown that EP2 and EP4 induce the activation of multiple signaling cascades that are associated with squamous cell carcinoma (SCC) [110,111]; human hepatocellular carcinoma (HCC) [112]; glioma [113]; prostate [114], bladder [115], endometrial [116], and breast cancer [117] cell growth. This evidence concerns the gene PTGER4 and hepatocellular carcinoma.