Higher production of proinflammatory TNFα and susceptibility to multiple sclerosis is also associated with some genetic variants in the NF-κB signaling cascade, such as variants proximal to NFκB1 and in an intron of TNFRSF1A (TNFR1), which leads to higher NF-κB signaling after stimulation with TNFα [59]. This evidence concerns the gene NFKB1 and multiple sclerosis.