CD4 and relapsing-remitting multiple sclerosis: There is also a lower percentage of circulating CD4+ CD25+Foxp3+ T cells, with lower capacity to suppress proliferation of autologous CD4+CD25+ T cells and a higher percentage of CD4+T-bet+ T cells with higher T-bet expression in RRMS patients, both in relapse and remission, than in healthy controls [38].