Moreover, Chung et al. reported that apoE was up-regulated in nasal secretomes that were obtained from chronic rhinosinusitis patients [136], a condition that is frequently associated with rhinitis [137], demonstrating that it can potentially be a biomarker of nasal mucosal inflammation [136], while increased levels of apoA-I were found in sinonasal mucosa obtained from chronic rhinosinusitis patients with nasal polyps [138]. This evidence concerns the gene APOE and chronic rhinosinusitis.