In particular, obesity-induced inflammation is associated with the downregulation of several genes associated with mitochondrial antioxidant biology such as glutathione S-transferase (Gsta4), aldehyde dehydrogenase (Aldh1), peroxiredoxin 3 (Prdx3) and glutathione peroxidase (Gpx4), as well as enzymes of the branched chain amino acid and tricarboxylic acid pathways [3,4,5]. This evidence concerns the gene GSTA4 and obesity due to melanocortin 4 receptor deficiency.