JAK2 and essential thrombocythemia: On the contrary, our study outlined not only the association between TET2 rs1548483 and each MPN phenotypes, but also the two major molecular subtypes seen in PV, ET and PMF, namely JAK2 V617F and CALR. In this respect, we noted significant association between TET2 rs1548483 variant allele and JAK2 V617F-positive PV and PMF.