Somatic mutations in the gene TET2 were originally described in 2009 by Delhommeau et al., and Langemeijer et al. They identified frequent somatic mutations in TET2 in MPNs, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) [17,18]. Here, TET2 is linked to myelodysplastic syndrome.