Similarly, Xiao et al. described the same SNP in JAK2 V617F-positive MPN patients, reporting a higher frequency of the TET2 SNP in JAK2 V617F high allele burden group than in the low allele burden group, suggesting that its presence may influence clinical characteristics and clonal evolution of MPN patients [35,36]. Here, JAK2 is linked to myeloproliferative neoplasm.