This genetic landscaping allowed the identification of germline SNPs that provided more evidence of an inherited cause for MPN, such as JAK2 46/1 or GGCC haplotype, and various other SNPs in genes such as TERT, MECOM, SH2B3, TET2, ATM, CHEK2, THRB-RARB, PINT [20,21,22,23,24,25,26,27]. Here, SH2B3 is linked to myeloproliferative neoplasm.