By showing significant associations between TET2 rs154843 SNP and various MPN phenotypes, such as PV and PMF, and molecular subtypes, such as JAK2 V617F-positive PV and PMF, type 2 CALR-positive PMF, we believe our study contributes to the addition of important data regarding the genetic landscape of MPN patients. This evidence concerns the gene JAK2 and acquired polycythemia vera.