We also identified epistatic interactions between TET2 rs154843 and HBS1L-MYB rs9376092 (pinteraction = 0.014 and pinteraction = 0.049 under codominant and overdominant model) and JAK2 rs10974944, which tags the JAK2 46/1 haplotype (pinteraction = 0.037 under recessive model) in ET. This evidence concerns the gene TET2 and essential thrombocythemia.