Hyper-IgE syndrome (HIES), also called Job’s syndrome or Buckley’s syndrome, was first described as a rare primary immunodeficiency disease characterized by recurrent staphylococcal “cold” skin and pulmonary abscesses, eczematoid dermatitis, markedly elevated levels of serum IgE and eosinophilia, reduced neutrophil chemotaxis, and variably impaired T cell function [14,15]. The gene discussed is IGHE; the disease is inborn error of immunity.