TARDBP and amyotrophic lateral sclerosis: For example, a SNP identified as a risk locus for ALS and FTD was found to contribute to cognitive decline, in vivo cortical degeneration in the prefrontal and temporal cortices, and post‐mortem pathologic burden of hyperphosphorylated TAR‐DNA binding protein [43 kDa] (TDP‐43) in the middle frontal, temporal, and motor cortices (Placek et al, 2019).