The most differentially down‐regulated genes after miR‐15a‐5p or miR‐21‐5p overexpression in our AML cell lines treated with daunorubicin are PDCD4, BTG2 and ARL2. It seems that the expression of both miRNAs was positively correlated in our patient series supporting a synergistic role on the same target genes and on chemoresistance. The gene discussed is PDCD4; the disease is acute myeloid leukemia.