Alongside, Breivik et al. demonstrated that the cardioprotective effect of coronary effluent applied after ischemia, as a postconditioning stimulus, was completely blocked when the Phosphoinositide 3-kinase (PI3K)-inhibitor wortmannin or the protein kinase B (Akt)-inhibitor SH-6 were administered [10]. Here, AKT1 is linked to ischemia.