Indeed, evidence of an intraocular renin-angiotensin system regulating important aspects of ocular physiology (e.g. retinal vascular tone and aqueous dynamic) has been demonstrated [12, 14], and viral ribonucleic acid has been detected by reverse transcription polymerase chain reaction (RT-PCR) in retinal biopsies of deceased COVID-19 patients [15], which together endorses the rationale for an ophthalmological syndrome of COVID-19, with some pathophysiology still unknown. This evidence concerns the gene REN and COVID-19.