Because women with signs and symptoms of ischemic heart disease (IHD) without obstructive CAD often have elevated resting left ventricular end-diastolic pressures (LVEDP) [15,16] and are at risk for heart failure hospitalizations [2], we hypothesized that NT-proBNP is related to CMD-related ischemia. This evidence concerns the gene NPPB and coronary artery disorder.