In the present study, we primarily found increased tmTNF-α expression and reduced sTNF-α secretion in heart tissues following systemic TNFR1 KO or cardiac TNFR1 KD and converse changes by TNFR2 KO/KD in TAC-induced cardiac hypertrophy. Here, TNFRSF1A is linked to persistent truncus arteriosus.