Furthermore, our data showed that tmTNF-α exerted beneficial effects via TNFR2 through activation of the AKT pathway, a cardioprotective signaling pathway [32–35], and inhibition of the NF-κB pathway, which is involved in cardiac hypertrophy, adverse remodeling, and inflammation [36–38]. This evidence concerns the gene TNFRSF1B and cardiac hypertrophy.