Moreover, the similar phenomena took place again at 4 weeks, later stage of TAC-induced cardiac hypertrophy, ventricular remodeling, fibrosis, and HF in WT, TNFR1-, and TNFR2-KO mice (S3A–S3L Fig, S3 Table). The gene discussed is TNFRSF1B; the disease is cardiac hypertrophy.