In addition, TNFR2 KO markedly increased TAC-induced left ventricular hypertrophy, manifested as enhanced LV mass normalized to body weight, LVPW,d, LVAW,d, and LVID,d (S1 Table) and thus exacerbated cardiac dysfunction, including decreased EF (Fig 1E) and FS (S1 Table), increased LVEDP, and reduced LVESP (S1 Table), dP/dtmax, and dP/dtmin (Fig 1F), and promoted cardiac fibrosis (S1E Fig) compared with those in WT mice. The gene discussed is TNFRSF1B; the disease is left ventricular hypertrophy.