ADAM17 and cardiac hypertrophy: Inhibition of TACE-mediated tmTNF-α processing by TAPI-1 ameliorated TAC-induced cardiac hypertrophy and the production of inflammatory cytokines, indicating that increased tmTNF-α expression and decreased sTNF-α release contributed to the beneficial effect of suppressing tmTNF-α processing in pressure overload-induced cardiac hypertrophy.