NRGN and Alzheimer disease: Behavioral phenotypes of commonly used AD model mice such as decreased nesting behavior,31, 35, 36, 37 hyperactivity,31, 37, 38, 39, 40, 41 impaired sociability,35 impaired working/reference memory,31, 35, 38, 39, 42, 43, 44, 45 and abnormal sensorimotor gating46, 47 overlap with those of Nrgn KO mice, which suggests the potential of Nrgn KO as a model of AD.