Staining with H&E, Masson trichrome, and Picro Sirius Red showed swollen, necrotic cardiomyocytes, broken, dissolved, and disorderly myocardial fibers, and obviously increased fibrosis in rats with VA‐HF that were coinjected with si‐SOX2‐OT and anti‐miR‐2355‐3p than with si‐SOX2‐OT and anti‐miR‐NC (Figure 4B). Here, SOX2 is linked to hydrops fetalis.