INS and hyperinsulinism: During hyperinsulinemia (180-300 minutes), mean glucose was successfully maintained at physiological concentration (lean placebo 5.32 ± 0.17 vs lean insulin 4.90 ± 0.13 vs obese placebo 5.25 ± 0.14 vs obese insulin 4.92 ± 0.26 mmol/L).