Histopathological analysis showed increased synovitis, pannus formation, as well as cartilage and bone destruction in the joints of 3-month-old TNF-Tg/Bad−/− mice compared with TNF-Tg littermates (Figure 6A,B), suggesting that Bad loss also exacerbates experimental arthritis in TNF-Tg model. This evidence concerns the gene TNF and arthritic joint disease.