The recipient mice were subjected to CIA 6 weeks after transplantation (Figure 3A), among which the mice transferred with Bad−/− bone marrow cells (CD45.1:Bad−/− mice) displayed more severe arthritis and higher incidence and clinical score than the mice transferred with WT bone marrow cells (CD45.1:WT mice) (Figure 3B,C). This evidence concerns the gene BAD and arthritic joint disease.