IHC staining of anti-pBAD (S99, equivalent to S136 in mouse) revealed that phosphorylation of human BAD (hBAD) at Ser99 was significantly higher in sublining layer of synovium of RA patients compared with that in OA patients (Figure 8A,B), consistent with the results in mouse arthritic joints (Figure 4B,C). The gene discussed is BAD; the disease is rheumatoid arthritis.