Similar to KEGG, most of the common enriched IPA pathways of DEGs and DNBs were associated with fibrosis, including hepatic fibrosis/HSC activation, HIF1α signalling, inhibition of matrix metalloproteases (MMP), LXR/RXR activation and retinol biosynthesis (Figure 4C1). The gene discussed is HIF1A; the disease is Hepatic fibrosis.