Nevertheless, in the present study, several other Th2 cytokines such as CCL2, CCL17 and CCL22, and furthermore cytokines of innate immunity, angiogenesis and vascular factors, did show differences between healthy and AD skin at baseline,6, 10, 11 and before and after TCS therapy, making tape stripping a useful technique for profiling biomarkers of a broad signature. Here, CCL22 is linked to Alzheimer disease.