By whole-exome sequencing of parathyroid adenomas, an activating missense mutation in the methyltransferase gene enhancer of zeste homolog 2 (EZH2) was detected in one out of 8 adenomas interrogated, and additional targeted sequencing of 185 adenomas revealed one additional case with the same mutation [66]. The gene discussed is EZH2; the disease is parathyroid gland adenoma.