CDC73 and parathyroid gland carcinoma: Given the increased parathyroid carcinoma risk in HPT-JT kindred as well as the association between somatic CDC73 mutations and sporadic parathyroid carcinoma, subsequent immunohistochemical analyses regarding parafibromin early-on proved of value to detect the majority of CDC73 mutated cases, including most parathyroid carcinomas [90, 91, 93–95, 118].