In this aspect, galectin-3 and PGP9.5 have both been shown to stain positive in the majority of parathyroid carcinomas while only expressed in few adenomas, and different panel combinations using galectin-3 and/or PGP9.5 with parafibromin have proven more reliable than using parafibromin alone [158-161]. This evidence concerns the gene LGALS3 and adenoma.