Multiple cytokines, including M-CSF (p<0.01), IP-10 (p<0.01), IL-18 (p=0.01) and IL-1RA (p<0.01) were more relevant in predicting COVID Severity Score than more frequently characterized cytokines in the context of COVID-19 such as IL-6 (p<0.01). This evidence concerns the gene IL18 and COVID-19.