PLD3 and Alzheimer disease: In some very small population groups, NGS has also discovered a number of susceptibility loci related to the development of AD, but GWAS usually missed them, such as ARSA, CHMP2B, CSF1R, FSIP2, GRN, IGHG3, NCSTN, NOS1AP, PLD3, TM2D3, TTC3, ZBTB4, and ZNF655 [76-82].