It is likely that BDNF plays a role in protecting against the progression of T2D, this has been supported by studies in mice [88, 99], where it has been shown that systemic administration of BDNF lowers blood glucose levels without fasting, without a significant reduction in food intake in obese, non-insulin-dependent diabetic mice [89]. The gene discussed is BDNF; the disease is type 2 diabetes mellitus.