ACE2 activators are purported to have two therapeutic effects: avoiding the binding of the S protein of SARS-CoV-2 to ACE2 and promoting the protective effects of different organs, preventing lung injury and fibrosis [34, 114, 115].ACE2 activators, such as diminazene aceturate, are recommended for application in COVID-19 patients [34]. The gene discussed is ACE2; the disease is COVID-19.