The findings of the present study have also uncovered that SCF+G-CSF treatment increases TREM2 expression in the Iba1+ microglia/macrophages surrounding the senile plaques, suggesting that TREM2 upregulation is involved in SCF+G-CSF-enhanced Aβ clearance by the Iba1+ microglia/macrophages in the senile plaques. The gene discussed is CSF3; the disease is Senile plaques.