Studies of serum markers have been reported to reflect the involvement of various mechanisms in the occurrence of AIS, such as brain natriuretic peptide (BNP) suggesting a cardiogenic mechanism, matrix metalloproteinase-9 (MMP-9) showing inflammatory mechanisms, cellular fibronectin (cFn) as a marker of HT, S100 calcium binding protein B (S-100B) and neuron specific enolase (NSE) reflecting brain injury [4,5]. This evidence concerns the gene NPPB and androgen insensitivity syndrome.