Thus, taking into account the heterogeneity of laboratory manifestations of the presence of LpX in plasma, we conclude that, in routine practice, any abnormalities in electrophoresis or discrepancies between electrophoresis and lipid-related biochemical tests (i.e. between electrophoresis and TG level or between TC and apoB levels) should be analysed very carefully and should raise suspicions of the presence of LpX, especially in hypercholesterolaemic patients with cholestasis. Here, APOB is linked to cholestasis.