Besides quinone oxidoreductase 1 (NQO1) and HMOX1, metallothionein 1G (MT1G) was identified as a new NFE2L2-targeted gene, which can drive ferroptosis resistance in HCC cells.127 The discovery of a large number of NFE2L2 target genes (e.g., FTH1, FTL, SLC40A1, glutathione synthetase (GSS), GCLC, SLC7A11, GPX4, aldehyde dehydrogenase 3 family member A1 (ALDH3A1), AKR1C, sestrin 2 (SESN2) and ferrochelatase (FECH)) further demonstrate the important antiferroptotic function of NFE2L2128 (Fig. 5b). The gene discussed is SESN2; the disease is hepatocellular carcinoma.