Certain selective types of autophagy (e.g., ferritinophagy,48,49 lipophagy,67 clockophagy118) and chaperone-mediated autophagy98 promote ferroptosis in various cancer cells through the degradation of ferroptosis repressors (e.g., ferritin, aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1), GPX4 and lipid droplets) (Fig. 4b, c). This evidence concerns the gene GPX4 and cancer.