The activation of the Hippo pathway promotes cadherin 1 (CDH1/E-cadherin)-dependent cell adhesion, resulting in ferroptosis resistance.139 In contrast, YAP1-mediated TFRC and ACSL4 expression, as well as WWTR1-mediated epithelial membrane protein 1 (EMP1) and angiopoietin-like 4 (ANGPTL4) expression, promotes ferroptosis in human renal cell carcinoma or ovarian cancer cells by increasing iron accumulation and lipid peroxidation.77,139 Like cell–cell contact,140 nectin cell adhesion molecule 4 (NECTIN4/PVRL4)-mediated cell clustering also prevents ferroptosis.141. This evidence concerns the gene EMP1 and hereditary clear cell renal cell carcinoma.