PLP1 and Pelizeaus-Merzbacher spectrum disorder: Hemoglobin- and hemin-induced toxicity reportedly involve both ferroptosis and necroptosis.175,176 Iron overload-induced ferroptosis is implicated in Pelizaeus-Merzbacher disease caused by mutations in proteolipid protein 1 (PLP1)177 or neuroferritinopathy.178 The ferroptosis inhibitor SRS11-92 is highly effective in protecting human primary fibroblasts from cell death induced by frataxin depletion, indicating that targeting ferroptosis might be useful for the treatment of Friedreich ataxia, pending confirmation in animal models.179