ACSL4 and inflammatory bowel disease: The heterozygous knockout of GPX4 in intestinal epithelial cells increases the inflammatory bowel disease (IBD) in mice caused by a PUFA-rich Western diet (containing 10% fish oil with omega-3 and omega-6 PUFAs).59 The inhibition of ferroptosis by liproxstatin-1 and rosiglitazone (an ACSL4 inhibitor) also reduces intestinal I/R injury.92 It remains to be seen whether chronic inflammation mediated by ferroptosis is related to colon cancer.