ACSL4 and inflammatory bowel disease: Omega-6, but not omega-3, PUFAs restore ferroptosis sensitivity in ACSL4-deficient cells.29 Dietary supplementation with mixed omega-6 and omega-3 PUFAs can favor the development of ferroptosis-related inflammatory bowel disease in mice.59 Thus, both omega-6 and omega-3 PUFAs seem to play a role in ferroptosis.