MDM4 and cancer: Podocyte-specific MDM2-knockout mice develop TP53-mediated kidney injury through the activation of a mixed type of cell death, including ferroptosis.134 However, another study shows that MDM2 and MDM4 regulator of p53 (MDM4/MDMX) promotes ferroptosis in cancer cells through the activation of peroxisome proliferator-activated receptor alpha (PPARA/PPARα), but not TP53.135 A profound comprehension of the role of TP53 in ferroptosis and other types of cell death may lead to the development of novel strategies for treating and preventing cancer.