SLC7A11 and triple-negative breast carcinoma: MUC1 can bind to the CD44 variant to enhance the stability of SLC7A11, thereby inhibiting erastin-induced ferroptosis in triple-negative breast cancer cells.88 In turn, silencing SLC7A11 increases H3K9 methylation (e.g., H3K9me2 and H3K9me3) of the MUC1 promoter, which may further affect GSH production during ferroptosis.88 The histone demethylase KDM3B prevents ferroptosis in HT1080 cells by upregulating SLC7A11 in an ATF4-dependent fashion.