HMGB1 and neoplasm: In general, ferroptosis is a form of inflammatory cell death associated with the release of DAMPs (e.g., high mobility group box 1 (HMGB1) and DNA) or lipid oxidation products (e.g., 4HNE, oxPLs, LTB4, LTC4, LTD4 and PGE2) during tissue injury or tumor therapy (Fig. 3).