Unlike HIF1A, endothelial PAS domain protein 1 (EPAS1, also known as HIF2A) appears to promote ferroptosis in clear cell carcinoma cells through transcriptional upregulation of hypoxia-inducible lipid droplet-associated (HILPDA/HIG2),144 a regulator of enriched lipids that contains polyunsaturated fatty acyl side chains.144 VHL-mediated β-oxidation or mitochondrial ATP synthesis inhibits ferroptosis in clear cell renal cell carcinoma through a GSH-independent manner.145 These findings indicate that HIF-mediated ferroptosis regulation is tumor type-dependent. This evidence concerns the gene EPAS1 and clear cell renal carcinoma.