PROM2 and breast carcinoma: The overexpression of SLC40A1 inhibits, whereas the knockdown of SLC40A1 increases, siramesine and lapatinib-induced ferroptosis through the modulation of iron efflux in breast cancer cells.52 Alternatively, prominin 2 (PROM2), a member of the prominin family of pentaspan membrane glycoproteins, causes ferroptosis resistance by stimulating exosome-dependent iron export through the formation of ferritin-containing multivesicular bodies in epithelial and breast carcinoma cells.53 Therefore, blocking the iron release pathway on cell membranes increases the susceptibility to ferroptosis.