Podocyte-specific MDM2-knockout mice develop TP53-mediated kidney injury through the activation of a mixed type of cell death, including ferroptosis.134 However, another study shows that MDM2 and MDM4 regulator of p53 (MDM4/MDMX) promotes ferroptosis in cancer cells through the activation of peroxisome proliferator-activated receptor alpha (PPARA/PPARα), but not TP53.135 A profound comprehension of the role of TP53 in ferroptosis and other types of cell death may lead to the development of novel strategies for treating and preventing cancer. This evidence concerns the gene MDM2 and cancer.