Similarly, GPX4 depletion in the kidney causes AKI in a ferroptosis-dependent manner.16 In contrast, growth factor, augmenter of liver regeneration (GFER/ALR) has a protective effect on I/R-induced kidney injury through binding to GPX4, further underscoring that GPX4 is a negative regulator of AKI. Here, GPX4 is linked to acute kidney injury.