The overexpression of SLC40A1 inhibits, whereas the knockdown of SLC40A1 increases, siramesine and lapatinib-induced ferroptosis through the modulation of iron efflux in breast cancer cells.52 Alternatively, prominin 2 (PROM2), a member of the prominin family of pentaspan membrane glycoproteins, causes ferroptosis resistance by stimulating exosome-dependent iron export through the formation of ferritin-containing multivesicular bodies in epithelial and breast carcinoma cells.53 Therefore, blocking the iron release pathway on cell membranes increases the susceptibility to ferroptosis. This evidence concerns the gene PROM2 and breast cancer.