T cell-specific Gpx4-deficient mice (TΔGpx4/ΔGpx4) were first used to study ferroptosis in immunity.35 Due to T-cell death by ferroptosis, TΔGpx4/ΔGpx4 mice are more sensitive to viral and parasitic infections.35 GPX4 is also important for the development of B1 and marginal zone B cells. This evidence concerns the gene GPX4 and parasitic infectious disease.