BAP1-encoded deubiquitinating enzyme (DUB) reduces histone 2A ubiquitination (H2Aub) on chromatin, leading to SLC7A11 downregulation and ferroptosis.87 In contrast, OTU deubiquitinase, ubiquitin aldehyde-binding 1 (OTUB1) directly stabilizes SLC7A11 through protein–protein interaction, and this process is further enhanced by CD44 in lung cancer cells.123 Therefore, the ratio of BAP1 over OTUB1 can determine the expression of SLC7A11. The gene discussed is OTUB1; the disease is lung cancer.