HELLS and ovarian cancer: Helicase, lymphoid-specific (HELLS/LSH), a chromatin remodeling factor, is a ferroptosis repressor through chromatin modification of SCD and fatty acid desaturases 2 (FADS2).150 SCD, an enzyme that catalyzes the rate-limiting step in the synthesis of MUFA, has the ability to inhibit ferroptosis in ovarian cancer cells.62 The expression of HELLS is positively regulated by transcription factor MYC and negatively regulated by HIF1A.150 This allows HELLS to respond quickly to changes in hypoxic environments and dynamically regulate many target genes.