LONP1-mediated degradation of transcription factor A, mitochondrial (TFAM) induces mitochondrial DNA damage, which causes ferroptosis in pancreatic cancer cells through the activation of stimulator of interferon response CGAMP interactor 1 (STING1/TMEM173)-dependent autophagy.20 These findings suggest that autophagy and UPS can engage in intertwined pathways to favor ferroptosis. Here, STING1 is linked to pancreatic neoplasm.