TP53 can transcriptionally inhibit SLC7A11 expression to induce GSH depletion and ferroptosis in human osteosarcoma, or breast or lung cancer cells to suppress tumor growth.85 This process is enhanced by TP53 acetylation at K117, K161, and K162 (hereafter p533KR/3KR), but limited by an additional TP53 acetylation at K98.130 TP53 also promotes ferroptosis through regulating lipid peroxidation via the transcriptional induction of SAT164 or GSL240 in human osteosarcoma cells or MEFs, respectively. Here, TP53 is linked to osteosarcoma.