Inducing ferroptosis also shows a benefit in enhancing the anticancer activity of checkpoint blockade (e.g., anti-CD274/PD-L1 and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA4)) and radiotherapy.169,170 Mechanistically, CD8+ T cell-mediated IFNG release inhibits SLC7A11 expression in cancer cells, thereby inducing tumor cell ferroptosis169 (Fig. 7a). This evidence concerns the gene CTLA4 and cancer.