This MUFA-induced ferroptosis resistance relies on ACSL3 or stearoyl-CoA desaturase (SCD/SCD1, an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid), instead of ACSL4.61,62 However, the MUFA oleic acid can induce ferroptosis in mice with acute lung injury,63 arguing that MUFA-mediated ferroptosis modulation is context-dependent. This evidence concerns the gene SCD and injury.