After treatment with SLC7A11 inhibitors (elastin and sorafenib), the protective effect of NFE2L2 in ferroptosis was first demonstrated in HCC cells.33 This process is further enhanced by SQSTM1 that increases NFE2L2 protein stability through the inactivation of kelch-like ECH-associated protein 1 (KEAP1), an adapter protein of the Cullin3-based ubiquitin E3 ligase complex responsible for NFE2L2 ubiquitination.33 The gene discussed is KEAP1; the disease is hepatocellular carcinoma.