The analysis of RSL3- or ML162-resistant KBM7 cells (a haploid chronic myeloid leukemia cell line) indicates two genes significantly enriched for gene trap insertions, namely ACSL4 and lysophosphatidylcholine acyltransferase 3 (LPCAT3).58 Indeed, the production of AA/AdA derivatives for ferroptosis requires ACSL4 and LPCAT3.24,28,29 ACSL4 first catalyzes the biochemical reaction of free AA/AdA to CoA to form AA/AdA-CoA derivatives and promotes their esterification into phospholipids, while LPCAT3 then catalyzes the biosynthesis of AA/AdA-CoA and membrane PE to form AA/AdA–PE (Fig. 2). Here, ACSL4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.