TP53 and bacterial infectious disease: TP53 and DPP4 are implicated in Golgi stress-induced ferroptosis.99 The S47 variant of TP53 (P47S) increases ferroptosis resistance in MEFs partly due to its impaired ability to induce GSL2 expression or elevated abundance of coenzyme A (CoA) and GSH production.132 In turn, the resulting ferroptosis deficiency causes iron to accumulate in P47S macrophages, increasing the risk of bacterial infection.133