HSPA5 and cancer: ACACA promotes FIN56-induced GPX4 degradation in HT1080 cells.70 Non-oxidized dopamine is a neurotransmitter that inhibits erastin-induced GPX4 degradation in cancer cells.97 Activating heat shock protein family A (Hsp70) member 5 (HSPA5) expression prevents erastin-induced GPX4 degradation through the formation of HSPA5–GPX4 protein complexes.95 In contrast, heat shock protein 90 (HSP90)-dependent chaperone-mediated autophagy promotes erastin-induced GPX4 degradation through recognizing its KFERQ-like motif (124NVKFD128 and 187QVIEK191) in neuronal cells98 (Fig. 4c).