Heat stress or HSF1-mediated expression of HSPB1 increases the resistance of cancer cells to ferroptosis through the inhibition of iron uptake.42 The cold stress-mediated activation of the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1)-MAPK14/p38 pathway also suppresses erastin- and RSL3-induced cell death.146 It is unclear whether different profiles of fat consumption under cold and heat stress may affect the propensity of cells to undergo ferroptosis. This evidence concerns the gene MAP3K5 and cancer.