CCR2 and metabolic dysfunction-associated steatohepatitis: Proinflammatory cytokine expression and macrophage infiltration are inhibited after CVC treatment, suggesting the involvement of a CCR2-dependent mechanism of macrophage migration in ALD.82 Thus, the two different types of infiltrating macrophages that are recruited to the liver likely play different or even opposite roles in regulating alcoholic liver inflammation and repair.83 In a recent publication, a fraction of KCs derived from Ly-6C+ monocytes was reported during NASH with underlying impairment of self-renewal ability.