HSD17B13 and metabolic dysfunction-associated steatohepatitis: Recently, several variants in the 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) gene were found to be associated with NASH inflammation, injury and fibrosis343,344 and with decreased development of HCC in individuals with ALD.345,346 HSD17B13 is a lipid droplet-associated protein with retinol dehydrogenase enzymatic activity.344 Importantly, the variants that lead to loss of enzymatic function are genetically associated with improved outcomes.