For example, several groups are interested in the potential therapeutic properties of G-CSF, a potent growth factor proposed to promote hepatocyte regeneration.136,153,154 IL-22 is a hepatoprotective cytokine that has been shown to protect against alcoholic hepatitis through multiple targets.106,155 Recently, an open-label, cohort dose-escalation phase IIa study revealed that treatment of patients with moderate and severe alcoholic hepatitis with IL-22 was safe and showed an improved mortality rate and clinical manifestations.156. Here, IL22 is linked to alcoholic hepatitis.