The pathways expressed in CD8+ and CD4+ T cells from highly diverse HCC are different from those expressed in T cells from less diverse HCC (EMT and myogenesis versus oxidative phosphorylation and interferon-α (IFN-α)/IFN-γ, respectively), which suggests that the HCC tumor transcriptome may indeed affect its immune microenvironment. This evidence concerns the gene CD8A and hepatocellular carcinoma.