FGFR4 and cancer: The most common genomic alteration in the FGFR family is gene amplification, with FGFR1 and FGFR4 having the highest frequencies of amplification seen in a study done by Helsten et al.3FGFR1 amplifications are common in multiple cancer types, including hormone-receptor positive (HR+), human epidermal growth factor receptor 2-positive (HER2+), and triple-negative breast cancer patients at frequencies of 23%, 27%, and 7%, respectively.