NTS and NTSR1 are coexpressed at high levels in more than 50% of HCC (NTSR1 being only weakly expressed in normal tissues); this coexpression correlates with aggressive biological behaviors: increase of EMT (epithelio-mesenchymal transition) features, e.g., decreased E-Cadherin expression and increased N-Cadherin and nuclear β-Catenin expressions. This evidence concerns the gene NTSR1 and hepatocellular carcinoma.