Further, we investigated whether LINC00998 induced apoptotic cell death in glioma and found that overexpression of LINC00998 increased annexin V positive cell rates in both A172 and U251 glioma cells, while knockdown of LINC00998 decreased annexin V positive cells in U373 (Supplementary Fig. S2). The gene discussed is ANXA5; the disease is central nervous system cancer.