To explore the possibility that endogenous CD4+ T cells are necessary for the improved antitumor response of m1928z-CD40L CAR T cell treatment, we took advantage of the finding that CD8+ CAR T cells alone, but not CD4+ CAR T cells, could cure A20.GL tumor-bearing mice (Supplementary Fig. 5A, B). The gene discussed is CD4; the disease is neoplasm.